About SALSA DB

Purpose

SALSA DB attempts to capture the current body of knowledge on how genetic alterations affect clinical actionability. As the field of precision medicine grows, the quantity of research on how specific alterations affect therapeutic response and patient prognosis expands at an increasing rate. SALSA DB seeks to curate this information from the literature, increasing the abilities of clinicians and researchers alike to rapidly assess the importance of an alteration.

Literature curation

SALSA DB draws primarily from primary research articles, review articles, and the NCCN guidelines. Data is curated through both expert review and using a Natural Language Processing (NLP) approach to select potentially informative articles from PubMed.

SALSA DB is co-developed with the PHIAL (Precision Heuristics for Interpreting the Alteration Landscape) algorithm, which draws from SALSA and other alterations databases to classify patient tumor data.

Predictive Implication Levels

SALSA DB classifies each curated assertion with a "predictive implication level" that describes the strength of the relationship between the given alteration and clinical action. The levels used are:

LevelDescription
FDA-Approved There is a validated association between the alteration and the recommended clinical action.
Level A The alteration is or has been used as an eligibility criterion for a clinical trial.
Level B There is limited early clinical evidence in support of this alteration/action relationship.
Level C There is limited early clinical evidence in support of this alteration/action relationship, but it is observed in a different tumor type.
Used in PHIAL, but not applicable to SALSA.
Level D There is preclinical evidence in support of this alteration/action relationship.
Level E There is inferential evidence in support of this alteration/action relationship.

Terms

SALSA DB is made available under the Open Database License (ODbL). A "plain-language" summary of the ODbL is available here.

You are free to share and modify the contents of SALSA DB under the following restrictions:

  1. All public use of the data (either in its entirety or in part) must be attributed.
  2. Any works produced using the data must also be licensed under the ODbL.
  3. Any works produced using the data must be open; if you distribute a version encumbered by technological restrictions (e.g., DRM), another version without such restrictions must be made available.
  4. All other terms of the ODbL must be followed.

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